Detailed Information

Cited 7 time in webofscience Cited 10 time in scopus
Metadata Downloads

Efficacy and safety of ecabet sodium on functional dyspepsia: A prospective, double-blinded, randomized, multi-center controlled trial

Authors
Lee, Jun HaengKim, Jae J.Hahm, Ki-BaikLee, Dong HoKim, NayoungKim, Sung KookPark, Jong JaeChoi, Seok ReyolLee, Jong HunLee, Soo TeikLee, Eun HyunRhee, Jong Chul
Issue Date
7-May-2006
Publisher
BAISHIDENG PUBLISHING GROUP INC
Keywords
functional dyspepsia; ecabet sodium; cimetidine
Citation
WORLD JOURNAL OF GASTROENTEROLOGY, v.12, no.17, pp.2756 - 2761
Indexed
SCIE
SCOPUS
Journal Title
WORLD JOURNAL OF GASTROENTEROLOGY
Volume
12
Number
17
Start Page
2756
End Page
2761
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18839
DOI
10.3748/wjg.v12.i17.2756
ISSN
1007-9327
Abstract
Aim: To compare ecabet sodium and cimetidine in relieving symptoms of functional dyspepsia. Methods: We performed a multi-center, prospective, randomized, double-blinded controlled trial to compare the clinical efficacy of ecabet sodium and cimetidine in patients with functional dyspepsia. Two-hundred and seventy-two patients with dyspeptic symptoms fulfilling the Rome-II criteria were enrolled from 7 centers. In the study group (115 patients), 1.5 g ecabet sodium was given twice a day. In the control group (121 patients), 400 mg cimetidine was given twice a day. Symptoms and parameters of quality of life were analyzed at baseline, 3, 14, and 28 d after initiating the treatment. Results: Two-hundred and thirty-six patients completed the clinical trial. After 4 wk of treatment, the rates of improvement in patients with dyspeptic symptoms were not different between two groups (77.4% in the ecabet group and. 79.3% in the cimetidine group, respectively, P>0.05). Likewise, the rates of symptomatic improvement were not different at 3 d and 14 d. The parameters of quality of life did not change significantly during the study period in both groups. There was no clinically significant adverse event in both groups. Conclusion: In patients with functional dyspepsia, ecabet sodium has similar clinical efficacy with cimetidine. (C) 2006 The WJG Press. All rights reserved.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Jong Jae photo

Park, Jong Jae
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE