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자살을 기도한 우울증 환자에서 사이토카인의 병태생리적 역할The Pathophysiological Role of Cytokines in Suicide Attempters with Major Depressive Disorder

Other Titles
The Pathophysiological Role of Cytokines in Suicide Attempters with Major Depressive Disorder
Authors
김성재김용구
Issue Date
Mar-2006
Publisher
대한신경정신의학회
Keywords
Cytokine; Depression; Suicide; Risk-rescue rating; Lethality of suicide attempt rating scale
Citation
신경정신의학, v.45, no.2, pp.117 - 127
Indexed
KCI
Journal Title
신경정신의학
Volume
45
Number
2
Start Page
117
End Page
127
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19021
ISSN
1015-4817
Abstract
OBJECTIVES Cytokines are known to play an important role in the pathogenesis and the pathophysiology of major depressive disorders. However, the role of cytokines in suicide in major depression has not been explored thoroughly. The purpose of this study is to identify the roles of cytokine interaction of Th1, Th2, Th3 cytokines in suicidal depressive patients. METHODS 110 major depressive patients (29 depressive patients without suicidal ideation, 32 depressive patients with suicidal ideation, and 49 depressive patients with suicide attempts) diagnosed by DSM-IV criteria were included in this study. The severity of suicide ideations and attempts was measured by Lethality of Suicide Attempt Rating Scale (LSARS) and Risk-Rescue Rating (RRR) system. Cytokine productions (TNF-alpha, IFN-gamma, IL-2, IL-4, and IL-6) upon mitogen stimulation were measured by ELISA in a whole blood assay. TGF-beta1 were measured in plasma by ELISA. RESULTS There were no significant differences in age, sex and BMI among the three groups. IL-2 and IL-6 levels were significantly lower in the suicide attempt group than other two groups while TNF-alpha, IFN-gamma, IL-4 and TGF-beta1 did not differ among the groups. Significant positive correlations between TNF-alpha/IL-4, IL-6/IL-4, IFN-gamma/IL-4 and IL-6/TGF-beta1 ratio and LSARS scores in suicidal patients were found. In addition, there were significant correlations between TNF-alpha/IL-4 or IL-6/IL-4 and RRR scores in suicidal patients. CONCLUSION These results indicate that decrease in Th1 cytokines may be associated with suicidal behavior in major depression. These findings suggest that cytokines may play a role in the pathogenesis of suicidal depression.
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