Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway
- Authors
- Hyeon S.K.; Yumkham S.; Kim S.-H.; Yea K.; You C.S.; Sung H.R.; Suh P.-G.
- Issue Date
- 2006
- Publisher
- Korean Society of Med. Biochemistry and Mol. Biology
- Keywords
- Mitogen-activated protein kinases; Neurites; Pheochromocytoma; Secretin; Tau proteins
- Citation
- Experimental and Molecular Medicine, v.38, no.1, pp 85 - 93
- Pages
- 9
- Indexed
- SCOPUS
KCI
- Journal Title
- Experimental and Molecular Medicine
- Volume
- 38
- Number
- 1
- Start Page
- 85
- End Page
- 93
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19299
- DOI
- 10.1038/emm.2006.10
- ISSN
- 1226-3613
2092-6413
- Abstract
- The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area, we have attempted to determine the effects of secretin on neuronal differentiation. Here, we report that secretin induces the generation of neurite outgrowth in pheochromocytoma PC12 cells. The expressions of Tau and beta-tubulin, neuronal differentiation markers, are increased upon secretin stimulation. In addition, secretin induces sustained mitogen-activated protein kinase (MAPK) activation and also stimulates the cAMP secretion. Moreover, the neurite outgrowth elicited by secretin is suppressed to a marked degree in the presence of either PD98059, a specific MAPK/ERK kinase (MEK) inhibitor, or H89, a specific protein kinase A (PKA) inhibitor. Taken together, these observations demonstrate that secretin induces neurite outgrowth of PC12 cells through cAMP- MAPK pathway, and provide a novel insight into the manner in which secretin participates in neuritogenesis.
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- Appears in
Collections - 1. Basic Science > Department of Anatomy > 1. Journal Articles
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