Pathogenesis and Mechanism of Obstructive Sleep Apnea폐쇄성 수면 무호흡증의 병인 및 기전
- Other Titles
- 폐쇄성 수면 무호흡증의 병인 및 기전
- Authors
- 최지호; 이승훈; 신철
- Issue Date
- Dec-2005
- Publisher
- 대한수면의학회
- Keywords
- Obstructive sleep apnea syndrome; pathogenesis; mechanism; treatment
- Citation
- SLEEP MEDICINE AND PSYCHOPHYSIOLOGY, v.12, no.2, pp 105 - 110
- Pages
- 6
- Journal Title
- SLEEP MEDICINE AND PSYCHOPHYSIOLOGY
- Volume
- 12
- Number
- 2
- Start Page
- 105
- End Page
- 110
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19388
- ISSN
- 1225-7354
2713-8631
- Abstract
- The pathogenesis and mechanism of obstructive sleep apnea (OSA) has been under investigation for over 25 years, but its etiology and mechanism remains elusive. Skeletal (maxillary and/or mandibular hypoplasia or retrodisplacement, inferior displacement of hyoid) and soft tissue (increased volume of soft tissue, adenotonsillar hypertrophy, macroglossia, thickened lateral pharyngeal walls) factors, pharyngeal compliance (increased), pharyngeal muscle factors (impaired strength and endurance of pharyngeal dilators and fixators), sensory factors (impaired mechanoreceptor sensitivity, impaired pharyngeal dilator reflexes), respiratory control system factors (unstable respiratory control) and so on facilitate collapse upper airway. Therefore, OSA may be a heterogeneous disorder, rather than a single disease entity and various pathogenic factors contribute to the OSA varies person to person. As a result, patients may respond to different therapeutic approaches based on the predominant abnormality leading to the sleep-disordered breathing.
- Files in This Item
-
Go to Link
- Appears in
Collections - 2. Clinical Science > Department of Pulmonary, Allergy, and Critical Care Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.