조기 양막파수에서 단핵구 CD14 수용체 유전자 증진자의 다형성에 대한 연구

Abstract

Objective: According to previous studies, Monocyte CD14 promoter gene polymorphisms were related to excessive inflammatory reaction mediated by monocyte. So we attempted too evaluate whether polymorphisms of the Monocyte CD 14 receptor promoter gene are associated with the development of PROM

Methods: We genotyped the CD14-260C/T polymorphism using PCR in 23 members of PROM group (group 1), 32 members of labor group without PROM (group 2) and 49 members of control group who admitted our hospital for cesarean surgery (group 3).

Results: Frequencies of the C and T alleles were determined to be 39.1% and 60.9% respectively in group 1, 34.4% and 65.6% in group 2, 34.7% and 65.3% in group 3. There were no statistical significances (p=0.8474). With regard to genotype, TT homozygote, CC homozygote and TC heterozygote were determined to be 21.7%, 0%, 78.3% respectively in group 1, 37.5%, 6.3%, 56.2% in group 2, 34.7%, 4.1% and 61.2% in group 3. There were no statistical significances between groups (p=0.4969)

Conclusion: There were no statistical significances between CD14 gene promoter polymorphisms and PROM. Relatively, small sample size and other many etiologic factors besides inflammation which can evoke PROM may influence our results.