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Cited 6 time in webofscience Cited 7 time in scopus
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Causal association between smoking behavior and the decreased risk of osteoarthritis: aMendelian randomization

Authors
Lee, Young Ho
Issue Date
Jun-2019
Publisher
Dr. Dietrich Steinkopff Verlag
Keywords
Smoking; Osteoarthritis; Mendelian randomization; Causal association; Susceptibility
Citation
Zeitschrift für Rheumatologie, v.78, no.5, pp.461 - 466
Indexed
SCIE
SCOPUS
Journal Title
Zeitschrift für Rheumatologie
Volume
78
Number
5
Start Page
461
End Page
466
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1966
DOI
10.1007/s00393-018-0505-7
ISSN
0340-1855
Abstract
Objective This study aimed to examine whether smoking behavior is causally associated with osteoarthritis. Methods A two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods was performed. We used the publicly available summary statistics datasets of smoking behavior genome-wide association studies (GWASs; n = 85,997) as an exposure, and a GWAS in 7410 patients with osteoarthritis in the arcOGEN study and 11,009 controls of European ancestry as an outcome. Results We selected four single nucleotide polymorphisms (SNPs) from GWASs of smoking behavior as instrumental variables (IVs) to improve inference. These SNPs were located at CHRNA3 (rs1051730), SLC25A5P5A9 (rs215614), CHRNB3 (rs6474412), and CYP2B6 (rs7260329). The IVW method showed evidence to support an inverse causal association between smoking behavior and osteoarthritis in the knee and hip (beta = −0.056, standard error [SE] = 0.027, p = 0.035). MR-Egger regression revealed that directional pleiotropy was unlikely to be biasing the result (intercept = −0.005; p = 0.848), but showed no causal association between smoking behavior and osteoarthritis (beta = −0.048, SE = 0.048, p = 0.427). However, the weighted median approach yielded evidence of a negative causal association between smoking behavior and osteoarthritis (beta = −0.056, SE = 0.028, p = 0.046). Cochran’s Q test and the funnel plot indicated no evidence of heterogeneity between IV estimates based on the individual variants. Conclusion The results of MR analysis support that smoking behavior was causally associated with a reduced risk of osteoarthritis.
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Lee, Young Ho
Anam Hospital (Department of Rheumatology, Anam Hospital)
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