Identification of novel electroconvulsive shock-induced and activity-dependent genes in the rat brain
- Authors
- Sun, W; Park, KW; Choe, J; Rhyu, IJ; Kim, IH; Park, SK; Choi, B; Choi, SH; Park, SH; Kim, H
- Issue Date
- 18-Feb-2005
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- electroconvulsive shock; microarray; neural activity; tissue remodeling
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.327, no.3, pp 848 - 856
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 327
- Number
- 3
- Start Page
- 848
- End Page
- 856
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19833
- DOI
- 10.1016/j.bbrc.2004.12.050
- ISSN
- 0006-291X
1090-2104
- Abstract
- Electroconvulsive shock (ECS) has been used as an effective treatment for patients suffering from major depression disorders and schizophrenia. However, the exact mechanisms underlying the action of ECS are poorly understood. Using high-density oligonucleotide microarrays, we identified 60 ECS-induced genes whose gene products are involved in the neuronal signaling, neuritogenesis and tissue remodeling. In situ hybridization and depolarization-dependent expression assay were performed to characterize 4 genes (lysyl oxidase, Ab1-046, SOX11, and T-type calcium channel I G subunit) which have not yet been reported to be induced by ECS. interestingly, the induction of these genes was observed mainly in the dentate gyrus of hippocampal formation and piriform cortex, where ECS-induced neural activation is highlighted, and depolarization of cultured cortical neurons also induced the expression of these genes. Taken together, our results suggest that therapeutic actions of ECS may be manifested by the activity-dependent induction of genes related to the plastic changes of the brain such as neuronal signaling neuritogenesis, and tissue remodeling. (C) 2004 Elsevier Inc. All rights reserved.
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- Appears in
Collections - 1. Basic Science > Department of Pharmacology > 1. Journal Articles
- 2. Clinical Science > Department of Neurology > 1. Journal Articles
- 1. Basic Science > Department of Anatomy > 1. Journal Articles
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