Inflammation, insulin resistance, and glucose intolerance in acute myocardial infarction patients without a previous diagnosis of diabetes mellitus
- Authors
- Choi, KM; Lee, KW; Kim, SG; Kim, NH; Park, CG; Seo, HS; Oh, DJ; Choi, DS; Baik, SH
- Issue Date
- Jan-2005
- Publisher
- ENDOCRINE SOC
- Keywords
- Inflammation; Insulin Resistance; Glucose Intolerance; Acute Myocardial Infarction
- Citation
- JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.90, no.1, pp 175 - 180
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Volume
- 90
- Number
- 1
- Start Page
- 175
- End Page
- 180
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19883
- DOI
- 10.1210/jc.2004-1795
- ISSN
- 0021-972X
1945-7197
- Abstract
- We examined the prevalence of impaired glucose metabolism and its association with inflammation and insulin resistance (IR) in acute myocardial infarction ( AMI) patients without a previous diagnosis of diabetes. This prospective study enrolled 52 AMI patients, and 75-g oral glucose tolerance testing was performed on 30 patients at discharge and again 3 months later. We also measured serum adiponectin, high sensitive C-reactive protein, and IL-6 on both occasions. Data were compared with those of 30 type 2 diabetic patients without a history of AMI. Forty percent and 36.7% of AMI patients had impaired glucose tolerance (IGT) at discharge and at 3 months, respectively. The corresponding proportions for newly diagnosed diabetes are 33.0% and 30.0%. At discharge, AMI patients with IGT or diabetes showed higher high sensitive C-reactive protein and IL-6 levels compared with AMI patients with normal glucose tolerance or control type 2 diabetic patients. Furthermore, AMI patients with IGT or diabetes exhibited higher IR and lower serum adiponectin levels than AMI patients with normal glucose tolerance at 3 months after discharge. Previously undiagnosed diabetes and IGT are common in Korean patients with AMI. These glycometabolic abnormalities are associated with inflammation, IR, and serum adiponectin levels.
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- Appears in
Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
- 2. Clinical Science > Department of Endocrinology and Metabolism > 1. Journal Articles
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