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A case of refractory pediatric Crohn's disease with a successful treatment by infliximab therapy

Authors
Park S.H.Jeen Y.T.Chun H.R.Kim D.I.Baeck C.W.Kim Y.S.Chun H.J.Lee H.S.Um S.H.Choi J.H.Kim C.D.Ryu H.S.Hyun J.H.
Issue Date
Oct-2005
Keywords
Crohn's disease; Pediatrics; Infliximab
Citation
The Korean journal of gastroenterology, v.46, no.4, pp 297 - 301
Pages
5
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of gastroenterology
Volume
46
Number
4
Start Page
297
End Page
301
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20057
ISSN
1598-9992
2233-6869
Abstract
Crohn's disease is a chronic inflammatory bowel disease which affects mainly children and young adults, and its cause remains unknown so far. Infliximab, a monoclonal antibody to the pivotal cytokine tumor necrosis factor-alpha, has been approved as a drug for both induction and maintenance therapy for moderately to severely active, or fistula-complicated Crohn's disease. The authors report a 12-year-old male patient diagnosed as Crohn's disease complicated with a perianal fistula, which was refractory to the conventional therapy. After the 0, 2, and 6 week scheduled intravenous infusion of infliximab, the patient reached to clinical remission in both subjective symptoms and objective manifestations. For children or young adults who develop Crohn's disease in a refractory course, infliximab may serve as a drug which leads to a clinical improvement or even to an extent of remission.
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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