Detailed Information

Cited 0 time in webofscience Cited 11 time in scopus
Metadata Downloads

Comparison of Helicobacter pylori eradication rate according to different PPI-based triple therapy--omeprazole, rabeprazole, esomeprazole and lansoprazole--

Authors
Keum B.Lee S.W.Kim S.Y.Kim J.M.Choung R.S.Yim H.J.Jeen Y.T.Lee H.S.Chun H.J.Um S.H.Choi J.H.Kim C.D.Ryu H.S.Hyun J.H.
Issue Date
Dec-2005
Keywords
Proton pump inhibitor; Helicobacter pylori; Eradication rate; 프로톤 펌프 억제제; 제균율
Citation
The Korean journal of gastroenterology, v.46, no.6, pp 433 - 439
Pages
7
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of gastroenterology
Volume
46
Number
6
Start Page
433
End Page
439
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20071
ISSN
1598-9992
2233-6869
Abstract
BACKGROUND/AIMS: Helicobacter pylori (H. pylori) is an important cause of various gastrointestinal diseases. H. pylori eradication is essential for the cure and prevention of associated diseases. Nowdays, proton pump inhibitor (PPI)-based triple therapy is the standard eradication regimen. The aims of this study were to compare the H. pylori eradication rate of different PPI-based triple therapies and to find out the factors influencing the eradication rate. METHODS: From May 2002 through February 2004, H. pylori infected patients were treated with the eradication regimen based on one of the four PPIs (omeprazole, rabeprazole, esomeprazole and lansoprazole) for 1 or 2 weeks. After two weeks, drug compliance, adverse effects, and smoking history during the eradication therapy were obtained. The follow-up H. pylori test was performed 4 weeks after the completion of therapy. The data were analyzed by Chi-square test and multiple logistic regression analysis. RESULTS: Overall eradication rate was 83.5%. There was no significant difference in eradication rate among four PPIs (p=0.379). Odds ratio (OR) for omeprazole and rabeprazole was 1.15 (95% CI 0.50-2.68); for omeprazole and esomeprazole, OR 1.63 (95% CI 0.68-3.89); and for omeprazole and lansoprazole, OR 1.13 (95% CI 0.50-2.56). Smoking habit, site of ulcer, and the duration of therapy affected the eradication rate significantly. CONCLUSIONS: The efficacy of four different PPIs for H. pylori eradication is similar to each other. Smoking, site of ulcer, and the duration of treatment have significant effects on eradication rates.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Chang Duck photo

Kim, Chang Duck
Others (Others(Others))
Read more

Altmetrics

Total Views & Downloads

BROWSE