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Comparison of Helicobacter pylori eradication rate according to different PPI-based triple therapy--omeprazole, rabeprazole, esomeprazole and lansoprazole--

Authors
Keum B.Lee S.W.Kim S.Y.Kim J.M.Choung R.S.Yim H.J.Jeen Y.T.Lee H.S.Chun H.J.Um S.H.Choi J.H.Kim C.D.Ryu H.S.Hyun J.H.
Issue Date
Dec-2005
Keywords
Proton pump inhibitor; Helicobacter pylori; Eradication rate; 프로톤 펌프 억제제; 제균율
Citation
The Korean journal of gastroenterology, v.46, no.6, pp.433 - 439
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of gastroenterology
Volume
46
Number
6
Start Page
433
End Page
439
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20071
ISSN
1598-9992
Abstract
BACKGROUND/AIMS: Helicobacter pylori (H. pylori) is an important cause of various gastrointestinal diseases. H. pylori eradication is essential for the cure and prevention of associated diseases. Nowdays, proton pump inhibitor (PPI)-based triple therapy is the standard eradication regimen. The aims of this study were to compare the H. pylori eradication rate of different PPI-based triple therapies and to find out the factors influencing the eradication rate. METHODS: From May 2002 through February 2004, H. pylori infected patients were treated with the eradication regimen based on one of the four PPIs (omeprazole, rabeprazole, esomeprazole and lansoprazole) for 1 or 2 weeks. After two weeks, drug compliance, adverse effects, and smoking history during the eradication therapy were obtained. The follow-up H. pylori test was performed 4 weeks after the completion of therapy. The data were analyzed by Chi-square test and multiple logistic regression analysis. RESULTS: Overall eradication rate was 83.5%. There was no significant difference in eradication rate among four PPIs (p=0.379). Odds ratio (OR) for omeprazole and rabeprazole was 1.15 (95% CI 0.50-2.68); for omeprazole and esomeprazole, OR 1.63 (95% CI 0.68-3.89); and for omeprazole and lansoprazole, OR 1.13 (95% CI 0.50-2.56). Smoking habit, site of ulcer, and the duration of therapy affected the eradication rate significantly. CONCLUSIONS: The efficacy of four different PPIs for H. pylori eradication is similar to each other. Smoking, site of ulcer, and the duration of treatment have significant effects on eradication rates.
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5. Others > Others(Medicine) > 1. Journal Articles
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Lee, Hong Sik
안암병원 (Department of Gastroenterology and Hepatology, Anam Hospital)
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