Peak expiratory flow variability and exercise responsiveness in methacholine-hyperresponsive adolescents with asthma remission
- Authors
- Young Y.K.; Kang H.; Yoo Y.; Yu J.; Kyu M.N.; Chang K.K.
- Issue Date
- 2005
- Keywords
- Adolescence; Asthma; Bronchial hyperresponsiveness; Clinical remission; Exercise challenge; Peak expiratory flow variability
- Citation
- Journal of Asthma, v.42, no.1, pp 17 - 23
- Pages
- 7
- Indexed
- SCOPUS
- Journal Title
- Journal of Asthma
- Volume
- 42
- Number
- 1
- Start Page
- 17
- End Page
- 23
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20094
- DOI
- 10.1081/JAS-200028014
- ISSN
- 0277-0903
1532-4303
- Abstract
- The aim of this study was to investigate whether bronchial hyperresponsiveness in adolescents with long-term asthma remission is associated with increased peak expiratory flow (PEF) variability and/or increased bronchial response to exercise (BRE). Twenty-nine adolescents with asthma remission (neither symptoms nor any medication used during the previous two years), but with persistent methacholine hyperresponsiveness (PC20 < 18 mg/mL; remission group), 29 methacholine PC20-matched adolescents with symptomatic asthma (symptomatic group), and 20 healthy subjects (control group) were studied. Subjects recorded PEF twice daily for 14 days and PEF variability, expressed as amplitude % mean, was calculated. Subjects also underwent a standardized exercise challenge; BRE was defined as a maximal % fall in FEV1 within 30 min after exercise. The mean (± SD) PEF variations in the symptomatic group and in the remission group were 12.10 ± 6.35% and 10.02 ± 4.73%, respectively, which were significantly higher than that (5.94 ± 2.44%) of the control group. On the other hand, the degree of BRE (7.36 ± 3.85%) in the remission group was significantly lower than that (22.31 ± 10.50%) of the symptomatic group, and similar to that (5.98 ± 2.70%) of the control group. Methacholine hyperresponsiveness in asthma remission during adolescence is associated with increased PEF variability but not with increased BRE. Copyright © 2005 Taylor & Francis Inc.
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- Appears in
Collections - 2. Clinical Science > Department of Pediatrics > 1. Journal Articles
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