Bronchial responsiveness and serum eosinophil cationic protein levels in preschool children with recurrent wheezing
- Authors
- Yu J.; Yoo Y.; Kim D.K.; Kang H.; Koh Y.Y.
- Issue Date
- 2005
- Publisher
- American College of Allergy, Asthma and Immunology
- Citation
- Annals of Allergy, Asthma and Immunology, v.94, no.6, pp 686 - 692
- Pages
- 7
- Indexed
- SCOPUS
- Journal Title
- Annals of Allergy, Asthma and Immunology
- Volume
- 94
- Number
- 6
- Start Page
- 686
- End Page
- 692
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20102
- DOI
- 10.1016/S1081-1206(10)61329-4
- ISSN
- 1081-1206
1534-4436
- Abstract
- Background: Bronchial hyperresponsiveness is a universally recognized phenomenon of asthma, and increased levels of eosinophil cationic protein (ECP) have been identified in the serum of patients with asthma. Objectives: To investigate whether enhanced bronchial responsiveness and elevated serum ECP levels are associated with recurrent wheezing in preschool children and to examine the possible relationship between these 2 variables. Methods: We recruited 130 children aged 4 to 6 years: 59 with at least 3 episodes of wheezing in the previous year (current wheezers), 38 with a documented history of wheezing before 3 years of age but no subsequent wheezing episodes (past wheezers), and 33 who had never experienced wheezing (nonwheezers). The children underwent methacholine bronchial provocation tests using a modified auscultation method and blood sampling for the measurement of ECP levels. Results: Current wheezers showed greater bronchial responsiveness than past wheezers and nonwheezers, as demonstrated by lower provocation concentrations that caused audible wheeze and lower provocation concentrations that caused a decline in oxygen saturation of at least 5% from baseline. Likewise, current wheezers had higher serum ECP levels than the other 2 groups. Among current wheezers, ECP levels showed a significant negative correlation with provocation concentrations that caused oxygen desaturation and a marginally significant correlation with provocation concentrations that caused audible wheeze. Conclusions: Enhanced bronchial responsiveness and elevated serum ECP levels are associated with recurrent wheezing in 4- to 6-year-old children. These results suggest that wheezing during preschool years may be phenotypically similar to wheezing in older children.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Pediatrics > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.