Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis
- Authors
- Kim C.K.; Kim S.W.; Kim Y.-K.; Kang H.; Yu J.; Yoo Y.; Koh Y.Y.
- Issue Date
- 2005
- Keywords
- Acute asthma; Acute bronchiolitis; Bronchoalveolar lavage; Eosinophil cationic protein; Interleukin-8
- Citation
- Clinical and Experimental Allergy, v.35, no.5, pp 591 - 597
- Pages
- 7
- Indexed
- SCOPUS
- Journal Title
- Clinical and Experimental Allergy
- Volume
- 35
- Number
- 5
- Start Page
- 591
- End Page
- 597
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20133
- DOI
- 10.1111/j.1365-2222.2005.02224.x
- ISSN
- 0954-7894
1365-2222
- Abstract
- Objective: In this study, we measured the levels of eosinophil cationic protein (ECP) and interleukin (IL)-8 in bronchoalveolar lavage (BAL) fluid from patients with acute asthma and acute bronchiolitis, to determine any similarities or dissimilarities in the profiles of these biochemical markers in the two diseases. Methods: BAL fluids were obtained from children with acute asthma (n = 16), infants with acute bronchiolitis caused by respiratory syncytial virus (n = 18), and control subjects (n = 14). Children with asthma were selected to be free of viral infection. BAL cell counts and differentials were determined, and ECP and IL-8 levels were measured by radioimmunoassay and ELISA, respectively. Results: ECP levels in BAL fluids were significantly higher in the asthma group than in the bronchiolitis (P < 0.01) or control (P < 0.0001) groups. However, IL-8 levels were significantly higher in the bronchiolitis group than in the asthma (P < 0.01) or control (P < 0.001) groups. IL-8 levels in the asthma group and ECP levels in the bronchiolitis group were similar to those of the control group. Conclusion: This difference in profiles of ECP and IL-8 in acute asthma and acute bronchiolitis, together with a different inflammatory cell pattern, suggests that the nature of the inflammatory process within the lower respiratory tract may be distinctive in these two diseases. © 2005 Blackwell Publishing Ltd.
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Collections - 2. Clinical Science > Department of Pediatrics > 1. Journal Articles
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