Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis
- Authors
- Wei D.; Gong W.; Oh S.C.; Li Q.; Kim W.D.; Wang L.; Le X.; Yao J.; Wu T.T.; Huang S.; Xie K.
- Issue Date
- 2005
- Keywords
- BONE MORPHOGENETIC PROTEIN-2; TRANSCRIPTION FACTOR; MEDIATED APOPTOSIS; MOLECULAR-BIOLOGY; EPITHELIAL-CELLS; GENE-EXPRESSION; STOMACH-CANCER; CARCINO
- Citation
- Cancer Research, v.65, no.11, pp 4809 - 4816
- Pages
- 8
- Indexed
- SCOPUS
- Journal Title
- Cancer Research
- Volume
- 65
- Number
- 11
- Start Page
- 4809
- End Page
- 4816
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20162
- DOI
- 10.1158/0008-5472.CAN-04-3741
- ISSN
- 0008-5472
- Abstract
- Identification of precise prognostic marker and effective therapeutic target is pivotal in the treatment of gastric cancer. In the present study, we determined the level of RUNX3 expression in gastric cancer cells and gastric cancer specimens and the impact of its alteration on cancer biology and clinical outcome. There was a loss or substantial decrease of RUNX3 protein expression in 86 cases of gastric tumors as compared with that in normal gastric mucosa (P < 0.0001), which was significantly associated with inferior survival duration (P = 0.0005). In a Cox proportional hazards model, RUNX3 expression independently predicted better survival (P = 0.036). Moreover, various human gastric cancer cell lines also exhibited loss or drastic decrease of RUNX3 expression. Enforced restoration of RUNX3 expression led to down-regulation of cyclin Dl but to up-regulation of p27, caspase 3, 7, and 8 expression, cell cycle arrest, and apoptosis in vitro, and dramatic attenuation of tumor growth and abrogation of metastasis in animal models. Therefore, we offered both clinical and mechanistic evidence that RUNX3 was an independent prognostic factor and a potential therapeutic target for gastric cancer © 2005 American Association for Cancer Research.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.