Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus
- Authors
- Gautam, Avishekh; Parke, Byoung Kwon; Kim, Te Ha; Akauliya, Madhav; Kim, Dongbum; Maharjan, Sony; Park, Joongwon; Kim, Jinsoo; Lee, Hanseul; Park, Man-Seong; Lee, Younghee; Kwon, Hyung-Joo
- Issue Date
- May-2019
- Publisher
- Frontiers Media S.A.
- Keywords
- apoptosis; cross protection; influenza A virus; neutralizing antibody; peritoneal cells
- Citation
- Frontiers in Immunology, v.10, no.MAY
- Indexed
- SCIE
SCOPUS
- Journal Title
- Frontiers in Immunology
- Volume
- 10
- Number
- MAY
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2018
- DOI
- 10.3389/fimmu.2019.01160
- ISSN
- 1664-3224
1664-3224
- Abstract
- Intraperitoneal inoculation with live influenza A virus confers protection against intranasal infections in mice and ferrets. However, the responses of peritoneal cells to influenza A virus have not been investigated. Here we show that intraperitoneal inoculation with ANVSN/1933 (H1N1) virus induced virus-reactive IgG production in the peritoneal cavity in mice. The infection resulted in substantial but transient B cell and macrophage depletion along with massive neutrophil infiltration, but virus growth was not detected. Influenza A viruses bound to alpha-2,6-linked sialic acids of B cells and macrophages and induced apoptotic death of peritoneal cavity cells. However, re-infection with A/WSN/1933 virus did not have adverse effects on immune cells most likely because of the neutralizing antibodies produced in response to the first exposure. Infection of BALB/c mice with ANVSN/1933 induced cross-protection against an otherwise lethal intraperitoneal dose of A/Hongkong/4801/2014 (H3N2) virus. This information suggests that immunological responses in the peritoneal cavity can induce effective defense against future virus infection. Considering the unexpected potent immunoregulatory activity of the peritoneal cells against influenza viruses, we suggest that comparative studies on various immune reactions after infection through different routes may contribute to better selection of vaccination routes in development of efficacious influenza vaccines.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 1. Basic Science > Department of Microbiology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.