Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder
- Authors
- Lee, Heon-Jeong; Lee, Min-Soo; Kang, Rhee-Hun; Kim, Hyun; Kim, Soon-Duck; Kee, Baik-Seok; Kim, Young Hoon; Kim, Yong-Ku; Kim, Jung Bum; Yeon, Byung Kil; Oh, Kang Seob; Oh, Byung-Hoon; Yoon, Jin-Sang; Lee, Chul; Jung, Han Yong; Chee, Ik-Seung; Paik, In Ho
- Issue Date
- Mar-2005
- Publisher
- WILEY-BLACKWELL
- Keywords
- PTSD; serotonin transporter; polymorphism
- Citation
- DEPRESSION AND ANXIETY, v.21, no.3, pp 135 - 139
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- DEPRESSION AND ANXIETY
- Volume
- 21
- Number
- 3
- Start Page
- 135
- End Page
- 139
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20182
- DOI
- 10.1002/da.20064
- ISSN
- 1091-4269
1520-6394
- Abstract
- Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by behavioral, physiologic, and hormonal alterations. The etioloxy of PTSD is unknown, although exposure to a traumatic event constitutes a necessary, but not Sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. The present study examined the possible association between the serotonin-transporter-linked polymorphic region (SERTPR) and PTSD. The genotype and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and 197 unrelated healthy controls using a case-control design. The frequency of the s/s genotype was significantly higher in PTSD patients than in normal controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. Further investigations are required into the influence of gene polymorphisms on the biological mechanisms of PTSD, its clinical expression, and its response to treatment. Depression and Anxiety 21:135-139, 2005. (c) 2005 Wiley-Liss, Inc.
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- Appears in
Collections - 1. Basic Science > Department of Preventive Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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