Cancer incidence among pesticide applicators exposed to chlorpyrifos in the agricultural health study
- Authors
- Lee, WJ; Blair, A; Hoppin, JA; Lubin, JH; Rusiecki, JA; Sandler, DP; Dosemeci, M; Alavanja, MCR
- Issue Date
- 1-Dec-2004
- Publisher
- OXFORD UNIV PRESS INC
- Citation
- JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, v.96, no.23, pp 1781 - 1789
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
- Volume
- 96
- Number
- 23
- Start Page
- 1781
- End Page
- 1789
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20194
- DOI
- 10.1093/jnci/djh324
- ISSN
- 0027-8874
1460-2105
- Abstract
- Background: Chlorpyrifos is one of the most widely used insecticides in the United States. We evaluated the incidence of cancer among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. Methods: A total of 54 383 pesticide applicators were included in this analysis. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered questionnaires completed at the time of enrollment (December 1993-December 1997). Poisson regression analysis was used to evaluate the association between chlorpyrifos exposure and cancer incidence after adjustment for potential confounders. All statistical tests were two-sided. Results: A total of 2070 incident malignant neoplasms were diagnosed through 2001. The rate ratio for all cancers combined among chlorpyrifos-exposed applicators compared with nonexposed applicators was 0.97 (95% confidence interval = 0.87 to 1.08). For most cancers analyzed, there was no evidence of an exposure-response relationship. However, the incidence of lung cancer was statistically significantly associated with both chlorpyrifos lifetime exposure-days (P-trend = .002) and chlorpyrifos intensity-weighted exposure days (P-trend = .036). After adjustment for other pesticide exposures and demographic factors, individuals in the highest quartile of chlorpyrifos lifetime exposure-days (>56 days) had a relative risk of lung cancer 2.18 (95% confidence interval = 1.31 to 3.64) times that of those with no chlorpyrifos exposure. Conclusion: Our findings suggest an association between chlorpyrifos use and incidence of lung cancer that deserves further evaluation.
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- Appears in
Collections - 1. Basic Science > Department of Preventive Medicine > 1. Journal Articles
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