Th1, Th2 and Th3 cytokine alteration in schizophrenia
- Authors
- Kim, YK; Myint, AM; Lee, BH; Han, CS; Lee, HJ; Kim, DJ; Leonard, BE
- Issue Date
- Nov-2004
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- antipsychotic; cytokine; interferon; interleukin; schizophrenia; TGF
- Citation
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.28, no.7, pp 1129 - 1134
- Pages
- 6
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Volume
- 28
- Number
- 7
- Start Page
- 1129
- End Page
- 1134
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20282
- DOI
- 10.1016/j.pnpbp.2004.05.047
- ISSN
- 0278-5846
1878-4216
- Abstract
- Background: Several studies have shown that there is an imbalance between T helper 1 (Th1) cytokines and T helper 2 (Th2) cytokines in patients with schizophrenia. The T helper 3 (Th3) cytokine, transforming growth factor beta-1 (TGF-beta1), has been shown to suppress the production of Th1 cytokines. Therefore it is hypothesized that it may play a role in schizophrenia by suppressing overactive Th1 system. Methods: We recruited 88 schizophrenic patients and 88 matched controls. The basal plasma concentrations of IFN-gamma (Th1), IL-4 (Th2) and TGF-beta1 (Th3) were studied at the time the patients were admitted to the hospital and following 8 weeks of treatment with antipsychotics. Results: The detection rate of plasma IFN-gamma and basal plasma TGF-beta1 level were significantly higher in schizophrenic patients than in controls whereas detection rate of plasma IL-4 was lower in patients. The ratio of Th1/Th2 cytokines (IFN-gamma/IL-4) was higher in schizophrenic patients. Following the neuroleptic treatment, the IFN-gamma and TGF-beta1 levels returned to control values, and IL-4 concentration rose above the control value. Conclusion: Schizophrenic patients showed higher Th1/Th2 ratio which is attenuated by effective neuroleptic treatment. It is possible that TGF-beta1 plays a role in reducing the activity of Th1 cytokine. (C) 2004 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.