Increased susceptibility to rheumatoid arthritis in Koreans heterozygous for HLA-DRB1*0405 and*0901
- Authors
- Lee, HS; Lee, KW; Song, GG; Kim, HA; Mm, SY; Bae, SC
- Issue Date
- Nov-2004
- Publisher
- WILEY
- Citation
- ARTHRITIS AND RHEUMATISM, v.50, no.11, pp 3468 - 3475
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARTHRITIS AND RHEUMATISM
- Volume
- 50
- Number
- 11
- Start Page
- 3468
- End Page
- 3475
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20290
- DOI
- 10.1002/art.20608
- ISSN
- 0004-3591
1529-0131
- Abstract
- Objective. To investigate the association of susceptibility and protective HLA-DRB1 alleles with rheumatoid arthritis (RA) and its clinical markers in an Asian population. Methods. All RA patients (n = 574) and control subjects (n = 392) were Korean. HLA-DRB1 typing and further subtyping of all alleles was performed by polymerase chain reaction, sequence-specific oligonucleotide probe hybridization, and direct DNA sequencing analysis. We used a relative predispositional effects (RPEs) method and a false discovery rate correction method for multiple comparisons. Results. The DRB1*0405 and *0901 alleles showed the most significant associations with RA (P = 7.83 X 10(-24), odds ratio [OR] 4.40 [95% confidence interval (95% CI) 3.24-5.99], and P = 3.76 X 10(-9), OR 2.47 [95% CI 1.82-3.36], respectively). The RPEs test showed that the DRB1*0401 and *0410 alleles conferred susceptibility and that the DRBI*0701, *0802, *1301, *1302, *1403, and *1405 alleles showed significant protective effects. Susceptibility and protective alleles both showed a pattern consistent with additive genetic effects, and each influenced RA independently of the other. The compound heterozygote DRB1*0405/*0901 was associated with the highest risk of RA (corrected P = 1.81 X 10(-11), OR 58.2 [95% CI 7.95-425.70]). The mean age at disease onset was similar to4 years earlier or was 3 years earlier, respectively, in patients with at least 1 copy of the DRB1*0405 or the DRB1*0901 allele. Radiographic changes (stages II-IV were more frequent in patients with at least 1 copy of DRB1*0405 (P = 0.032, 92.6% versus 84.3%, OR 2.33 [95% CI 1.244.39]). Conclusion. The DRB1*0405/*0901 heterozygote has the strongest association with RA, suggesting that this heterozygote enhances the susceptibility to RA in Koreans.
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Collections - 2. Clinical Science > Department of Rheumatology > 1. Journal Articles
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