Efficacy of 14 day OBMT therapy as a second-line treatment for Helicobacter pylori infection
- Authors
- Park S.C.; Chun H.J.; Jung S.W.; Keum B.; Han W.S.; Choung R.S.; Kim Y.S.; Jeen Y.T.; Lee H.S.; Um S.H.; Lee S.W.; Choi J.H.; Kim C.D.; Ryu H.S.; Hyun J.H.
- Issue Date
- Sep-2004
- Keywords
- Helicobacter pylori; Retreatment; Eradication; 재치료; 제균율
- Citation
- The Korean journal of gastroenterology, v.44, no.3, pp 136 - 141
- Pages
- 6
- Indexed
- SCOPUS
KCI
- Journal Title
- The Korean journal of gastroenterology
- Volume
- 44
- Number
- 3
- Start Page
- 136
- End Page
- 141
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20808
- ISSN
- 1598-9992
2233-6869
- Abstract
- BACKGROUND/AIMS: As a second-line treatment for H. pylori eradication in the case of first-line OAC (omeprazole, amoxicillin, clarithromycin) treatment failure, a minimum of one-week OBMT quadruple therapy composed of omeprazole, bismuth, metronidazole, tetracycline has been recommended in European countries and one or two weeks in USA. In Korea, one-week OBMT quadruple therapy is recommended for the case of first-line OAC treatment failure. Because H. pylori eradication rate of one-week OBMT therapy in Korea is about 80%, the eradication rate of one week therapy is not satisfactory. We analyzed the effect of two-week second-line OBMT therapy. METHODS: Between June 2002 and June 2003, 107 patients who were H. pylori positive (44 males and 63 females: mean age 51.8 years) after primary eradication therapy received two-week OBMT therapy. Four weeks after completion of therapy, 13C-urea breath test was performed to detect H. pylori. RESULTS: After two weeks of OBMT therapy, eradication was achieved in 103 of 107 patients (96.3%) and in 68 of 71 peptic ulcer patients (95.8%). CONCLUSIONS: Two-week OBMT therapy should be considered as a retreatment regimen with the eradication rate more than 90%.
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- Appears in
Collections - 2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
- 5. Others > Others(Medicine) > 1. Journal Articles
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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