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Efficacy of 14 day OBMT therapy as a second-line treatment for Helicobacter pylori infection

Authors
Park S.C.Chun H.J.Jung S.W.Keum B.Han W.S.Choung R.S.Kim Y.S.Jeen Y.T.Lee H.S.Um S.H.Lee S.W.Choi J.H.Kim C.D.Ryu H.S.Hyun J.H.
Issue Date
Sep-2004
Keywords
Helicobacter pylori; Retreatment; Eradication; 재치료; 제균율
Citation
The Korean journal of gastroenterology, v.44, no.3, pp.136 - 141
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of gastroenterology
Volume
44
Number
3
Start Page
136
End Page
141
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20808
ISSN
1598-9992
Abstract
BACKGROUND/AIMS: As a second-line treatment for H. pylori eradication in the case of first-line OAC (omeprazole, amoxicillin, clarithromycin) treatment failure, a minimum of one-week OBMT quadruple therapy composed of omeprazole, bismuth, metronidazole, tetracycline has been recommended in European countries and one or two weeks in USA. In Korea, one-week OBMT quadruple therapy is recommended for the case of first-line OAC treatment failure. Because H. pylori eradication rate of one-week OBMT therapy in Korea is about 80%, the eradication rate of one week therapy is not satisfactory. We analyzed the effect of two-week second-line OBMT therapy. METHODS: Between June 2002 and June 2003, 107 patients who were H. pylori positive (44 males and 63 females: mean age 51.8 years) after primary eradication therapy received two-week OBMT therapy. Four weeks after completion of therapy, 13C-urea breath test was performed to detect H. pylori. RESULTS: After two weeks of OBMT therapy, eradication was achieved in 103 of 107 patients (96.3%) and in 68 of 71 peptic ulcer patients (95.8%). CONCLUSIONS: Two-week OBMT therapy should be considered as a retreatment regimen with the eradication rate more than 90%.
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Jung, Sung Woo
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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