Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure
- Authors
- Kobayashi H.; Jo S.-K.; Kawamoto S.; Yasuda H.; Hu X.; Knopp M.V.; Brechbiel M.W.; Choyke P.L.; Star R.A.
- Issue Date
- 2004
- Keywords
- Acute renal failure; Contrast media; Kidney; Magnetic resonance imaging; Polyamine dendrimer
- Citation
- Journal of Magnetic Resonance Imaging, v.20, no.3, pp 512 - 518
- Pages
- 7
- Indexed
- SCOPUS
- Journal Title
- Journal of Magnetic Resonance Imaging
- Volume
- 20
- Number
- 3
- Start Page
- 512
- End Page
- 518
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20874
- DOI
- 10.1002/jmri.20147
- ISSN
- 1053-1807
1522-2586
- Abstract
- Purpose: To choose an efficacious renal functional MRI contrast agent to image early renal tubular damage. We synthesized and compared smaller polyamine dendrimer-based MRI contrast agents (<60 kD) that, unlike Gd-[DTPA], transiently accumulate in renal tubules and can be used to visualize renal structural and functional damage. Materials and Methods: Six dendrimer-based MRI contrast agents smaller than 60 kD were studied by high resolution dynamic micro-MRI and compared to Gd-[DTPA]-dimeglumine and Gadomer-17. The best agent, DAB-G2, was further tested in a mouse ischemia/reperfusion model to validate its efficacy. Results: Despite unequal renal clearance rates, all polyamine dendrimer agents visualized the renal functional anatomy of the mice better than Gd-[DTPA]-dimeglumine and Gadomer-17. DAB-G2 was excreted most rapidly, yet was able to visualize mild renal tubular injury very early after injury. Conclusion: DAB-G2 was found to be the best candidate for functional kidney imaging and enabled early diagnosis of acute renal injury.
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- Appears in
Collections - 2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
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