Clinical Features of Patients With Spontaneous Intracranial Hypotension Complicated With Bilateral Subdural Fluid Collections

Abstract

BackgroundSubdural hygromas are often found bilaterally in spontaneous intracranial hypotension (SIH). They frequently progress to chronic subdural hematomas (CSDHs), and if the hematomas are formed, it is difficult to consider SIH as an underlying cause. Whether SIH is underlying or not among the patients presenting bilateral subdural fluid collections (hygromas or CSDHs) is clinically important because the treatment strategy should be different between them. ObjectivesWe designed a retrospective case-control study to figure out differential clinical features of the patients presenting bilateral symptomatic subdural fluid collections owing to SIH. MethodsSixty-two patients with bilateral symptomatic subdural fluid collections were enrolled, and their data on general demographics, clinical courses, radiological findings, treatments, and outcomes were collected. The patients were divided into SIH and Non-SIH groups, and a simple logistic regression analysis was performed to clarify the differences between the groups. The consequent receiver operating characteristics (ROC) curve analyses were performed with the significant predictors. ResultsEight patients (13%) were diagnosed with SIH. Young age (odds ratio [OR]=0.831, 95% confidence interval [CI]: 0.743-0.929, P=.0012), no underlying disease (OR=0.062, 95% CI: 0.007-0.544, P=.0121), radiological features of brain sagging (OR=10.36, 95% CI: 0.912-93.411, P=.0017), pseudo-subarachnoid hemorrhage (OR=15.6, 95% CI: 2.088-116.52, P=.0074), and small amount of fluid collections (OR=0.719, 95% CI: 0.579-0.893, P=.0029) were significantly associated with SIH group. ROC curve analyses were performed in parameters of age and amount of fluid collection and the cut-off values for each parameter were 55 years old and 22.08 mm, respectively. Patients diagnosed with SIH underwent epidural blood patches and showed good results, except 1 patient who underwent burr-hole trephinations. ConclusionBilateral subdural fluid collections due to underlyingSIH isassociated with young age (55 years old), no underlying diseases, smaller amount of fluid collections (22.08 mm of depth), and radiologicalfindings of brain sagging or pseudo-subarachnoid hemorrhages.