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Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population

Authors
Lee, HJLee, HSKim, YKKim, SHKim, LLee, MSJoe, SHJung, IKSuh, KYKim, S
Issue Date
1-Apr-2003
Publisher
WILEY-LISS
Keywords
novelty seeking; persistence; polymorphism; DRD4
Citation
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, v.118B, no.1, pp.76 - 80
Indexed
SCIE
SCOPUS
Journal Title
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume
118B
Number
1
Start Page
76
End Page
80
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/21268
DOI
10.1002/ajmg.b.10047
ISSN
0148-7299
Abstract
Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young (approximate to14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and -521 C/T, there was no direct correlation with the personality traits. (C) 2003 Wiley-Liss, Inc.
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Lee, Heon Jeong
Anam Hospital (Department of Psychiatry, Anam Hospital)
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