Submucosal CD4+ and CD8+ T Lymphocyte Infiltrations in Asthma and Eosinophilic Bronchitis
- Authors
- Lee S.Y.; Lee S.Y.; Kim J.H.; Shin C.; Shim J.J.; Kang K.H.; Yoo S.H.; In K.H.; Jeong W.Y.; Lee J.H.; Kim H.K.
- Issue Date
- 2003
- Publisher
- Korean National Tuberculosis Association
- Keywords
- Asthma; CD4+; CD8+; Eosinophilic bronchitis; Lymphocyte
- Citation
- Tuberculosis and Respiratory Diseases, v.55, no.5, pp 459 - 466
- Pages
- 8
- Indexed
- SCOPUS
- Journal Title
- Tuberculosis and Respiratory Diseases
- Volume
- 55
- Number
- 5
- Start Page
- 459
- End Page
- 466
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/21487
- DOI
- 10.4046/trd.2003.55.5.459
- ISSN
- 0378-0066
- Abstract
- Background: Asthma and eosinophilic bronchitis (EB) are eosinophilic inflammatory diseases of the airway. However, EB differs from asthma in that there is no variable airway obstruction or airway hyper-responsiveness. Pathologically, asthma is characterized by the accumulation of eosinophils and CD4+ T lymphocytes in the submucosa. A recent study showed that there was no significant difference between asthma and EB in terms of the submucosal eosinophil and T lymphocyte count. However, it is not known whether or not an infiltration of CD4+ and CD8+ T lymphocytes occurs in the airways of EB patients. The aim of this study was to identify the difference between the two conditions by measuring the submucosal CD4+ and CD8+ T lymphocyte count. Methods: Immunohistochemical analysis of bronchial-biopsy specimens was performed in 17 subjects with asthma and 24 subjects with EB. Results: The CD4+ T lymphocytes count in the asthma subjects and the EB subjects was similar (median, 58.6 vs 50.0 cells/mm2, respectively; P=0.341). In contrast, the number of CD8+ T lymphocytes in the EB subjects was higher than that in the asthma subjects (median, 46.7 vs 11.8 cells/mm2, respectively; P=0.003). Conclusion: The infiltration of submucosal CD8+ T lymphocytes may be associated with the pathophysiology of EB.
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- Appears in
Collections - 2. Clinical Science > Department of Pathology > 1. Journal Articles
- 2. Clinical Science > Department of Pulmonary, Allergy, and Critical Care Medicine > 1. Journal Articles
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