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A case of auto-immune hepatitis associated with primary Sjogren's syndrome

Authors
Kwon Y.D.Lee H.S.Park C.H.Jeen Y.T.Chun H.J.Lee S.W.Choi J.H.Kim C.D.Ryu H.S.Hyun J.H.
Issue Date
2003
Keywords
Hepatitis/Autoimmune; Sj& ouml; gren’s syndrome; 간염/자가면역성; 원발성 쇼그렌 증후군
Citation
Taehan Kan Hakhoe chi = The Korean journal of hepatology, v.9, no.1, pp.25 - 30
Indexed
SCOPUS
Journal Title
Taehan Kan Hakhoe chi = The Korean journal of hepatology
Volume
9
Number
1
Start Page
25
End Page
30
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/21503
ISSN
1226-0479
Abstract
Auto-immune hepatitis is a chronic necroinflammatory liver disorder that is characterized by hypergammaglobulinemia, auto-antibodies in serum, and, on histological examination, the presence of periportal hepatitis. Although it can be associated with a number of other auto-immune diseases, Sjogren's syndrome is rarely associated with auto-immune hepatitis. We herein report an unusual case of auto-immune hepatitis associated with primary Sjogren's syndrome. A 39-year-old woman was admitted to our hospital due to jaundice. Laboratory data showed negative viral hepatitis marker, increased serum IgG level, positive anti- nuclear antibody, and an increased rheumatoid factor titer. The patient had no history of taking medications and alcohol. Based on characteristic clinical features, liver biopsy findings, positive Schirmer's test, and salivary scintigraph, she was diagnosed as having auto-immune hepatitis and Sjogren's syndrome. The patient achieved complete remission with steroid monotherapy.
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