Antimicrobial peptide LL-37 is upregulated in chronic nasal inflammatory disease
- Authors
- Kim, ST; Cha, HE; Kim, DY; Han, GC; Chung, YS; Lee, YJ; Hwang, YJ; Lee, HM
- Issue Date
- 2003
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- antimicrobial peptide; LL-37; nose; pro-inflammatory cytokines
- Citation
- ACTA OTO-LARYNGOLOGICA, v.123, no.1, pp 81 - 85
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACTA OTO-LARYNGOLOGICA
- Volume
- 123
- Number
- 1
- Start Page
- 81
- End Page
- 85
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/21577
- DOI
- 10.1080/0036554021000028089
- ISSN
- 0001-6489
1651-2251
- Abstract
- Objective-LL-37 is one of the antimicrobial peptides and the only member of the cathelicidin family identified so far in humans. We attempted to find a correlation between LL-37 peptide and inflammation of the nasal mucosa. Material and methods-Nasal mucosa specimens were obtained from 15 chronic infective rhinitis patients and 6 normal controls. Immunohistochemical staining was used to examine the localization of LL-37 and reverse transcriptase polymerase chain reaction (RT-PCR) was used to determine the levels of LL-37, IL-1beta and IL-8 in tissue. Results-LL-37 peptide was primarily localized in the surface of the epithelia, in the serous and mucous cells of the submucosal glands and in stromal inflammatory cells. The number of LL-37 immunoreactive cells in inflammatory nasal mucosa was significantly increased compared with normal nasal tissue. Using RT-PCR, LL-37 mRNA was detected in 3/6 normal turbinate samples but in all cases with inflammatory nasal tissues. IL-1beta and IL-8 transcripts exhibited a similar pattern to that of LL-37. Conclusions-We suggest that LL-37 is one of the antimicrobial peptides found in human nasal mucosa and that it participates in the innate immune system of the nasal mucosa.
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Collections - 2. Clinical Science > Department of Otorhinolaryngology-Head and Neck Surgery > 1. Journal Articles
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