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Cited 2 time in webofscience Cited 2 time in scopus
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Gender- and cholesterol-specific predictive value of body mass index in renal cell carcinoma: A multicenter studyopen access

Authors
Jeong, Hyun CheolBashraheel, Fahad K.Byun, Seok-SooKwak, CheolHwang, Eu ChangKang, Seok HoChung, JinsooKim, Tae-HwanKim, Yong-JuneHong, Sung-Hoo
Issue Date
Apr-2019
Publisher
WILEY
Keywords
body mass index; cholesterol; gender; multicenter study; predictive value; renal cell carcinoma
Citation
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, v.15, no.2, pp E36 - E42
Indexed
SCIE
SCOPUS
Journal Title
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
Volume
15
Number
2
Start Page
E36
End Page
E42
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2208
DOI
10.1111/ajco.13073
ISSN
1743-7555
1743-7563
Abstract
Aim Recently, there have been some reports on preoperative body mass index (BMI) and total cholesterol (TC) as a prognostic predictor for patients with renal cell carcinoma (RCC) but the topic is controversial and still poorly understood. So we analyzed the effects of BMI and TC on the prognosis of RCC. Methods Retrospective data from 1988 to 2015 were collected from eight centers with a total of 7,271 patients surgically treated for nonmetastatic RCC. Receiver operating characteristic curve analysis was analyzed and the highest Youden index was shown at 163.5 mg/dL. According to the Asian BMI criteria, patients were divided into normal BMI < 25 kg/m(2) and high BMI >= 25 kg/m(2). Kaplan-Meier analysis, multivariate Cox regression model were performed to identify the overall survival (OS) and the recurrence-free survival (RFS). Results Normal BMI and low TC group was associated with the shortest OS and RFS as compared to the other groups significantly. In the male patients, the results showed similar to the whole sample. But in the female, BMI had no effect on both OS and RFS. On multivariate Cox regression analysis, low TC was an independent predictor for OS in both genders. However, normal BMI was a significant prognostic factor in the males only. Conclusion Preoperative BMI and TC are good predictive factors for both OS and RFS significantly in RCC patients. Also, TC was an independent predictor for OS in all RCC patients; however, BMI was a significant predictor in males only.
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