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Cited 12 time in webofscience Cited 14 time in scopus
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Genipin Enhances the Therapeutic Effects of Oxaliplatin by Upregulating BIM in Colorectal Cancer

Authors
Kim, Bo RamJeong, Yoon A.Jo, Min JeePark, Seong HyeNa, Yoo JinKim, Jung LimJeong, So yeonYun, Hye KyeongKang, SangheeLee, Dae HeeOh, Sang Cheul
Issue Date
Apr-2019
Publisher
American Association for Cancer Research
Citation
Molecular Cancer Therapeutics, v.18, no.4, pp.751 - 761
Indexed
SCIE
SCOPUS
Journal Title
Molecular Cancer Therapeutics
Volume
18
Number
4
Start Page
751
End Page
761
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2215
DOI
10.1158/1535-7163.MCT-18-0196
ISSN
1535-7163
Abstract
Despite an increase in the survival rate of patients with cancer owing to the use of current chemotherapeutic agents, adverse effects of cancer therapies remain a concern. Combination therapies have been developed to increase efficacy, reduce adverse effects, and overcome drug resistance. Genipin is a natural product derived from Gardenia jasminoides, which has been associated with anti-inflammatory, anti-angiogenic, and anti-proliferative effects; hypertension; and anti-ischemic brain injuries. However, the enhancement of oxaliplatin sensitivity by genipin remains unexplored. Our study showed that a combination of genipin and oxaliplatin exerts synergistic antitumor effects in vitro and in vivo in colorectal cancer cell lines through the reactive oxygen species (ROS)/endoplasmic reticulum (ER) stress/BIM pathway. Importantly, the combination did not affect normal colon cells. BIM knockdown markedly inhibited apoptosis induced by the combination. In addition, genipin induced ROS by inhibiting superoxide dismutase 3 activity. These findings suggest that genipin maybe a novel agent for increasing the sensitivity of oxaliplatin against colorectal cancer. The combination of oxaliplatin and genipin hold significant therapeutic potential with minimal adverse effects.
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2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
3. Graduate School > Graduate School > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles

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Kang, Sang hee
구로병원 (Department of Colon and Rectal Surgery, Guro Hospital)
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