Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish
- Authors
- Kim S.-H.; Shin J.; Park H.-C.; Yeo S.-Y.; Hong S.-K.; Han S.; Rhee M.; Kim C.-H.; Chitnis A.B.; Huh T.-L.
- Issue Date
- 2002
- Keywords
- Anterior neuroectoderm; Brain patterning; Diencephalon; Eye primordia; Fz8a; Midbrain; Wnt8b; Zebrafish
- Citation
- Development, v.129, no.19, pp 4443 - 4455
- Pages
- 13
- Indexed
- SCOPUS
- Journal Title
- Development
- Volume
- 129
- Number
- 19
- Start Page
- 4443
- End Page
- 4455
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/22187
- ISSN
- 0950-1991
1477-9129
- Abstract
- Wnts have been shown to provide a posteriorizing signal that has to be repressed in the anterior neuroectoderm for normal anteroposterior (AP) patterning. We have previously identified a zebrafish frizzled8a (fz8a) gene expressed in the presumptive anterior neuroectoderm as well as prechordal plate at the late gastrula stage. We have investigated the role of Fz8a-mediated Wnt8b signalling in anterior brain patterning in zebrafish. We show that in zebrafish embryos: (1) Wnt signalling has at least two different stage-specific posteriorizing activities in the anterior neuroectoderm, one before mid-gastrulation and the other at late gastrulation; (2) Fz8a plays an important role in mediating anterior brain patterning; (3) Wnt8b and Fz8a can functionally interact to transmit posteriorizing signals that determine the fate of the posterior diencephalon and midbrain in late gastrula embryos; and (4) Wnt8b can suppress fz8a expression in the anterior neuroectoderm and potentially affect the level and/or range of Wnt signalling. In conclusion, we suggest that a gradient of Fz8a-mediated Wnt8b signalling may play crucial role in patterning the posterior diencephalon and midbrain regions in the late gastrula.
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Collections - 3. Graduate School > Biomedical Research Center > 1. Journal Articles
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