The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs
- Authors
- Kim, YK; Suh, IB; Kim, H; Han, CS; Lim, CS; Choi, SH; Licinio, J
- Issue Date
- 2002
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- interleukin-12; schizophrenia; major depression; mania; inflammatory response system; cytokine
- Citation
- MOLECULAR PSYCHIATRY, v.7, no.10, pp 1107 - 1114
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULAR PSYCHIATRY
- Volume
- 7
- Number
- 10
- Start Page
- 1107
- End Page
- 1114
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/22200
- DOI
- 10.1038/sj.mp.4001084
- ISSN
- 1359-4184
1476-5578
- Abstract
- Interleukin-12 (IL-12) plays a key role in promoting T helper 1 (Th1) responses and subsequent cell-mediated immunity. Given the role of cytokines in the pathogenesis of psychiatric disorders, the dysregulation of IL-12 in these illnesses would be expected. We measured the plasma levels of IL-12 in 102 psychiatric patients (43 schizophrenia, 34 major depression and 25 bipolar disorder) and 85 normal controls. In addition, IL-12 levels of the patients were measured after an 8-week treatment to assess whether the levels were affected by medication. The IL-12 levels of the patient group with major depression were significantly higher than that of the control group, whereas no differences were found among the other groups. IL-12 values of the three patient groups decreased significantly after 8 weeks of treatment. These findings support the hypothesis that activation of the inflammatory response system and in particular of Th-1-like cells, is involved in the pathophysiology of major depression and that repeated administration of antidepressive and antipsychotic drugs may suppress IL-12 plasma concentrations in psychiatric patients.
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- Appears in
Collections - 2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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