Circadian disruption and increase of oxidative stress in male and female volunteers after bright light exposure before bed time
- Authors
- Lee, Hyo-Sun; Lee, Eunil; Moon, Joung-Ho; Kim, Yun Jeong; Lee, Heon-Jeong
- Issue Date
- Apr-2019
- Publisher
- KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
- Keywords
- Circadian disruption; Bright light; Before bedtime; Cortisol; Oxidative stress; Male and Female
- Citation
- Molecular & Cellular Toxicology, v.15, no.2, pp 221 - 229
- Pages
- 9
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Molecular & Cellular Toxicology
- Volume
- 15
- Number
- 2
- Start Page
- 221
- End Page
- 229
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2223
- DOI
- 10.1007/s13273-019-0025-9
- ISSN
- 1738-642X
2092-8467
- Abstract
- Backgrounds
Circadian rhythms are patterns of behaviour, physiology, and metabolism that occur within a period of approximately 24 h. The higher risk of breast and prostate cancers among shift workers, as well as the general population, are reported to be associated with circadian rhythm disruption caused by exposure to light at night. We focused on the effects of bright light before bed comparing effects between men and women.
Methods
Male and female healthy volunteers aged 20–30 were exposed to 4 hours of bright light before bed for 3 and 4 days.
Results
We analyzed the shift of circadian rhythms of subjects based on cortisol secretion patterns in response to short periods of bright-light exposure at bedtime. We also found an increase of oxidative stress including MDA, 8-OHdG, and total antioxidants in both male and female volunteers.
Conclusion
These results suggest that bright light exposure before sleep, often encounter in modern daily life, has a considerable influence on the human body. The chronic effects of light exposure before bed time such as the carcinogenic effects caused by circadian disruption and oxidative stress need further investigation.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
- 1. Basic Science > Department of Preventive Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.