Natural history of low-grade squamous intraepithelial lesion
- Authors
- Saw H.-S.; Lee J.-K.; Lee H.-L.; Jee H.-J.; Hyun J.-J.
- Issue Date
- 2001
- Keywords
- HPV DNA test; LGSIL; Natural history
- Citation
- Journal of Lower Genital Tract Disease, v.5, no.3, pp 153 - 158
- Pages
- 6
- Indexed
- SCOPUS
- Journal Title
- Journal of Lower Genital Tract Disease
- Volume
- 5
- Number
- 3
- Start Page
- 153
- End Page
- 158
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/22826
- DOI
- 10.1046/j.1526-0976.2001.53007.x
- ISSN
- 1089-2591
1526-0976
- Abstract
- Objective. To determine guidelines for management of CIN1 by evaluating its natural history. Methods. One hundred fifty-eight patients were diagnosed with CIN1 had colposcopy follow-up with or without cytology every three months. Results. Colposcopically directed biopsy confirmed progression to CIN2 or CIN3 in 17 of 158 (10.7%) patients, persistence of CIN1 in 87 (55%) patients, regression to normal in 54 (34.2%) patients during the 5-year follow-up period. The percentage of abnormal Pap tests were 39%, 64%, and 71% in the regression, persistent, and progression groups, respectively. The percentage of HPV-positive tests were 16%, 29%, 65% in regression, persistent, and progression groups, respectively. Conclusions. Of the patients who were diagnosed with CIN1 and monitored by colposcopy for 60 months, 34% had disease regression, 55% had persistent disease, and 11% had progressive disease. HPV DNA testing is more informative than the Pap test in the prediction of disease progression.
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- Appears in
Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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