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Anticonvulsant effects of new morphinan derivatives
- Authors
- Kim H.-C.; Nabeshima T.; Jhoo W.-K.; Ko K.H.; Kim W.-K.; Shin E.-J.; Cho M.; Lee P.H.
- Issue Date
- 2001
- Citation
- Bioorganic and Medicinal Chemistry Letters, v.11, no.13, pp 1651 - 1654
- Pages
- 4
- Indexed
- SCOPUS
- Journal Title
- Bioorganic and Medicinal Chemistry Letters
- Volume
- 11
- Number
- 13
- Start Page
- 1651
- End Page
- 1654
- ISSN
- 0960-894X
1464-3405
- Abstract
- We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects. © 2001 Elsevier Science Ltd.
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Collections - 1. Basic Science > Department of Neuroscience > 1. Journal Articles
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Related Researcher
- Kim, Won Ki
- College of Medicine (Department of Neural Sciences)