Effect of risperidone on serum cytokines
- Authors
- Kim, DJ; Kim, W; Yoon, SJ; Go, HJ; Choi, BM; Jun, TY; Kim, YK
- Issue Date
- 2001
- Publisher
- GORDON BREACH PUBLISHING, TAYLOR & FRANCIS GROUP
- Keywords
- schizophrenia; interleukin; risperidone; cytokine
- Citation
- INTERNATIONAL JOURNAL OF NEUROSCIENCE, v.111, no.1-2, pp 11 - 19
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Volume
- 111
- Number
- 1-2
- Start Page
- 11
- End Page
- 19
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/22878
- DOI
- 10.3109/00207450108986549
- ISSN
- 0020-7454
1563-5279
- Abstract
- A variety of cytokines are dysregulated in schizophrenia, and some antipsychotic drugs effect cytokines. In order to examine the effect of risperidone on plasma cytokines, we measured the serum level of IL-1b, IL-2, IL-6, IL-12, and INF-6 during acute states of illness, and after 4 weeks of treatment with risperidone in 19 schizophrenic patients. The patients' psychopathology was assessed by PANSS. Plasma IL-12 levels increased significantly after 4 weeks of treatment (p = .002). Plasma IL-b, IL-2, IL-6, and INF-g levels were not significantly different before and after treatment. There were no significant correlations between the changes in cytokine levels and the changes in PANSS scores. Increased IL-12 may contribute to activation of immune responses during treatment with risperidone. IL-12 may play an important role in immune responses related to neuropsychiatry.
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- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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