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Cited 13 time in webofscience Cited 12 time in scopus
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Diallyl disulfide (DADS) boosts TRAIL-Mediated apoptosis in colorectal cancer cells by inhibiting Bcl-2

Authors
Kim, Hong JunKang, SangheeKim, Dae YeoungYou, SanguanPark, DaehoOh, Sang CheulLee, Dae-Hee
Issue Date
Mar-2019
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
TRAIL-Resistance; Diallyl disulphide; Bcl-2; Death receptor 5
Citation
FOOD AND CHEMICAL TOXICOLOGY, v.125, pp.354 - 360
Indexed
SCIE
SCOPUS
Journal Title
FOOD AND CHEMICAL TOXICOLOGY
Volume
125
Start Page
354
End Page
360
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2357
DOI
10.1016/j.fct.2019.01.023
ISSN
0278-6915
Abstract
Ever since several targeted agents were introduced a decade ago, progress in new therapeutic strategies for colorectal cancer (CRC) has been much slower than that for other cancers. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is widely known to induce cellular apoptosis in numerous cancer cell types. However, many cancer cells are resistant to the effects of TRAIL, and thus, approaches are needed to overcome TRAIL resistance. We demonstrated that non-cytotoxic doses of diallyl disulfide (DADS) increased TRAIL-associated cell death in CRC cell lines. Additionally, synergistic effects between DADS and TRAIL were validated in vivo in nude mice. One process involved in these effects includes down-regulation of the anti-apoptotic protein Bcl-2, and the synergistic effect of DADS with TRAIL was attenuated in Bcl-2-over-expressing cells. Taken together, the results of this study give new insights into the role of DADS in TRAIL-related repression of CRC progression by inhibition of Bcl-2.
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3. Graduate School > Graduate School > 1. Journal Articles
2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles

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Oh, Sang Cheul
Guro Hospital (Department of Medical Oncology and Hematology, Guro Hospital)
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