CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth
- Authors
- Cho-Chung Y.S.; Park Y.G.; Nesterova M.; Lee Y.N.; Cho Y.S.
- Issue Date
- 2000
- Keywords
- Ap-1; cAMP; CRE; Gene expression; p53; Transcription factor-decoy oligonucleotides; Tumor growth
- Citation
- Molecular and Cellular Biochemistry, v.212, no.1-2, pp 29 - 34
- Pages
- 6
- Indexed
- SCOPUS
- Journal Title
- Molecular and Cellular Biochemistry
- Volume
- 212
- Number
- 1-2
- Start Page
- 29
- End Page
- 34
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/23627
- DOI
- 10.1023/A:1007144618589
- ISSN
- 0300-8177
1573-4919
- Abstract
- Nucleic acid molecules with high affinities for a target transcription factor can be introduced into cells as decoy cis-elements to bind these factors and alter gene expression. This review discusses a synthetic single-stranded palindromic oligonucleotide, which self-hybridizes to form a duplex/hairpin and competes with cAMP response element (CRE) enhancers for binding transcription factors. This oligonucleotide inhibits CRE- and Ap-1-directed gene transcription and promotes growth inhibition in vitro and in vivo in a broad spectrum of cancer cells, without adversely affecting normal cell growth. Evidence presented here suggests that the CRE-decoy oligonucleotide can provide a powerful new means of combating cancers, viral diseases, and other pathological conditions by regulating the expression of cAMP-responsive genes.
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- Appears in
Collections - 1. Basic Science > Department of Biochemistry and Molecular Biology > 1. Journal Articles
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