GABA and L-theanine mixture decreases sleep latency and improves NREM sleep
DC Field | Value | Language |
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dc.contributor.author | Kim, Suhyeon | - |
dc.contributor.author | Jo, Kyungae | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Han, Sung Hee | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.date.available | 2020-11-02T06:43:53Z | - |
dc.date.issued | 2019-02-01 | - |
dc.identifier.issn | 1388-0209 | - |
dc.identifier.issn | 1744-5116 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2394 | - |
dc.description.abstract | Context: gamma-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter and it is well established that activation of GABAA receptors favours sleep. L-Theanine, a naturally occurring amino acid first discovered in green tea, is a well-known anti-anxiety supplement with proven relaxation benefits. Objective: This study investigated the potential synergistic sleep enhancement effect of GABA/L-theanine mixture. Materials and methods: Pentobarbital-induced sleep test was applied to find proper concentration for sleep-promoting effect in ICR mice. Electroencephalogram (EEG) analysis was performed to investigate total sleeping time and sleep quality in normal SD rats and caffeine-induced awareness model. Real-time polymerase chain reaction (RT-PCR) was applied to investigate whether the sleep-promoting mechanism of GABA/L-theanine mixture involved transcriptional processes. Results: GABA/L-theanine mixture (100/20mg/kg) showed a decrease in sleep latency (20.7 and 14.9%) and an increase in sleep duration (87.3 and 26.8%) compared to GABA or theanine alone. GABA/L-theanine mixture led to a significant increase in rapid eye movement (REM) (99.6%) and non-REM (NREM) (20.6%) compared to controls. The use of GABA/L-theanine mixture rather than GABA or L-theanine alone restored to normal levels sleep time and quality in the arousal animal model. The administration of GABA/L-theanine led to increased expression of GABA and the glutamate GluN1 receptor subunit. Conclusions: GABA/L-theanine mixture has a positive synergistic effect on sleep quality and duration as compared to the GABA or L-theanine alone. The increase in GABA receptor and GluN1 expression is attributed to the potential neuromodulatory properties of GABA/L-theanine combination, which seems to affect sleep behaviour. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | GABA and L-theanine mixture decreases sleep latency and improves NREM sleep | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1080/13880209.2018.1557698 | - |
dc.identifier.scopusid | 2-s2.0-85060932055 | - |
dc.identifier.wosid | 000468852200002 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICAL BIOLOGY, v.57, no.1, pp 65 - 73 | - |
dc.citation.title | PHARMACEUTICAL BIOLOGY | - |
dc.citation.volume | 57 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 73 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | GREEN TEA | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | GLUTAMATE | - |
dc.subject.keywordPlus | RELAXATION | - |
dc.subject.keywordPlus | CAFFEINE | - |
dc.subject.keywordPlus | INSOMNIA | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | ABUSE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | g-Aminobutyric acid | - |
dc.subject.keywordAuthor | insomnia | - |
dc.subject.keywordAuthor | pentobarbital-induced sleep test | - |
dc.subject.keywordAuthor | electroencephalography | - |
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