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Apoptotic changes in a full-lengthened immobilization model of rat soleus muscle
- Issue Date
- Feb-2019
- Publisher
- John Wiley & Sons Inc.
- Keywords
- apoptosis; Bax; casting; lengthened immobilization; lengthening; soleus
- Citation
- Muscle and Nerve, v.59, no.2, pp 263 - 269
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Muscle and Nerve
- Volume
- 59
- Number
- 2
- Start Page
- 263
- End Page
- 269
- ISSN
- 0148-639X
1097-4598
- Abstract
- Introduction: Lengthened immobilization may prevent muscle shortening, and help maintain normal muscle length. However, its apoptotic effects remain unclear. We evaluated the effects of long-term immobilization on apoptotic proteins. Methods: Rat soleus muscles were immobilized by casting in a neutral (NEUT) or lengthened (LENG) position for 21 days. We evaluated dynamic weight load and muscle atrophy following the 21-day period using hematoxylin and eosin staining. We measured Bax (pro-apoptotic Bcl-2 family member), MyoD (myogenic differentiation factor D), MYH (myosin heavy chain), and cleaved poly(ADP-ribose)polymerase levels and examined apoptotic nucleus expression. Results: Decreased dynamic weight load and muscle atrophy changes were observed in LENG. Both NEUT and LENG showed significantly reduced levels of MYH. LENG showed a significant increase in Bax and MyoD expression as well as in the number of apoptotic nuclei. Conclusions: Long-term lengthened immobilization may increase apoptotic changes and decrease muscle formation proteins in muscle. Muscle Nerve 59:263-269, 2019
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Related Researcher
- Han, Hee Chul
- College of Medicine (Department of Physiology)