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Cited 56 time in webofscience Cited 74 time in scopus
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Cryoglobulinemia and rheumatic manifestation in patients with hepatitis C virus infection

Authors
Lee, Young HoJi, Jong DaeYeon, Jong EunByun, Kwan SooLee, Chang HongSong, Gwan Gyu
Issue Date
Dec-1998
Publisher
BMJ Publishing Group
Citation
Annals of the Rheumatic Diseases, v.57, no.12, pp 728 - 731
Pages
4
Indexed
SCOPUS
Journal Title
Annals of the Rheumatic Diseases
Volume
57
Number
12
Start Page
728
End Page
731
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/24786
DOI
10.1136/ard.57.12.728
ISSN
0003-4967
1468-2060
Abstract
OBJECTIVES To investigate the association of cryoglobulinaemia and rheumatic manifestations in Korean patients with hepatitis C virus (HCV) infection. METHODS Forty nine Korean patients with HCV infection were recruited. The prevalence, concentration, and type of cryoglobulin (by immunofixation), rheumatoid factor (RF), antinuclear antibody (ANA), and various rheumatological symptoms were investigated and HCV genotype was determined by polymerase chain reaction with genotype specific primer. RESULTS The prevalence of cryoglobulin was 59% in Korean HCV patients and the concentration of cryoglobulin was 9.8 (7.9) g/l (mean (SD)). The type of cryoglobulinaemia was identified in 23 (80%) of 29 HCV patients with cryoglobulinaemia and they were all type III. There were no differences in age, sex, history of operation and transfusion, proportion of liver cirrhosis between the patients with cryoglobulinaemia and those without cryoglobulinaemia. The frequencies of RF and ANA were 14% and 3.4% respectively in HCV patients with cryoglobulinaemia. There was no difference in HCV genotype between the patients with cryoglobulinaemia and those without cryoglobulinaemia. Clinical features of HCV patients were as follows: arthralgia/arthritis (35%), cutaneous manifestation (37%), Raynaud’s phenomenon (8%), paresthesia (44%), dry eyes (22%), dry mouth (10%), oral ulcer (33%), and abdominal pain (14%). However, these rheumatological symptoms did not differ between the two groups. CONCLUSION Although the rheumatological symptoms were not different between HCV patients with and without cryoglobulinaemia, HCV patients showed various rheumalogical manifestations. These result suggests that HCV infection could be included as one of the causes in patients with unexplained rheumatological symptoms.
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