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Activity-dependent conduction velocity changes of A delta fibers in a rat model of neuropathy
- Issue Date
- 20-Oct-1997
- Publisher
- RAPID SCIENCE PUBLISHERS
- Keywords
- activity dependence; axon; conduction block; conduction velocity; dorsal root fiber; hyperalgesia; neuropathy; primary afferent nerve
- Citation
- NEUROREPORT, v.8, no.15, pp 3201 - 3205
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROREPORT
- Volume
- 8
- Number
- 15
- Start Page
- 3201
- End Page
- 3205
- ISSN
- 0959-4965
1473-558X
- Abstract
- ACTIVITY-DEPENDENT changes of conduction velocity (CV) and conduction block in single A delta fibers of primary afferent neurons were characterized in a rat model of neuropathy (NP). Injured dorsal root (DR) fiber in NP rats exhibited profoundly greater decreases of CV following impulse activity than did DR fiber in normal rats. Activity-dependent conduction block was absent up to 100 Hz of activity rate in DR fiber of NP rats, but was present above 25 Hz in normal rats. Profiles of activity dependence in sciatic fibers were similar in both NP and normal rats. These results suggest that nerve injury may alter activity-dependent hypoexcitability of A delta DR fibers. Furthermore, this excitability change may be responsible for the elevated pain perception in neuropathy.
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Collections - 1. Basic Science > Department of Physiology > 1. Journal Articles
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Related Researcher
- Kim, Yang In
- College of Medicine (Department of Physiology)