Increased plasma complement factor H is associated with geriatric depression
- Authors
- Shin, Cheolmin; Ham, Byung-Joo; Ko, Young-Hoon; Pae, Chi-Un; Park, Moon Ho; Steffens, David C.; Patkar, Ashwin A.; Han, Changsu
- Issue Date
- Jan-2019
- Publisher
- CAMBRIDGE UNIV PRESS
- Keywords
- complement factor H; geriatric depression; complement system; alternative pathway
- Citation
- INTERNATIONAL PSYCHOGERIATRICS, v.31, no.1, pp 101 - 108
- Pages
- 8
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- INTERNATIONAL PSYCHOGERIATRICS
- Volume
- 31
- Number
- 1
- Start Page
- 101
- End Page
- 108
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2564
- DOI
- 10.1017/S1041610218000558
- ISSN
- 1041-6102
1741-203X
- Abstract
- Background: Complement factor H (CFH) plays a key role in regulating the cascade of the alternative pathway of the complement system. Dysregulation of CFH may be involved in the pathophysiology of various inflammation-mediated diseases including neuropsychiatric illnesses. This study aimed to investigate this relationship by examining determining CFH levels in elderly individuals with and without depression. Methods: A total of 152 elderly individuals (major depressive disorder (MDD) group, n = 76; comparison sample, n = 76) were selected from the Ansan Geriatric study. The plasma level of CFH was measured. MDD was diagnosed with the Mini-International Neuropsychiatric Interview as per DSM-IV criteria. The severity of depression was evaluated with the geriatric depression scale (GDS). Mean CFH levels were compared using the Mann-Whitney U test. After adjusting for possible confounding factors including age, sex, marital status, education, alcohol use, hemoglobin levels, and the Korean version of the Mini-Mental State Examination (MMSE-KC), a multiple regression analysis was conducted. The GDS score and plasma level of CFH were analyzed using Spearman's correlation. Results: Plasma CFH level was significantly higher in individuals with MDD than in the comparison sample (289.51 +/- 21.16 vs. 339.67 +/- 66.23, p < 0.001). In a regression model adjusted for possible confounders, CFH was significantly associated with geriatric depression (p < 0.001). CFH levels were not significantly related to GDS scores in the depressed group. Conclusion: This study revealed an association between high plasma levels of CFH and geriatric depression, thereby suggesting the alternative pathway of the complement system contributing to the development of geriatric depression.
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- Appears in
Collections - 2. Clinical Science > Department of Neurology > 1. Journal Articles
- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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