Relationship between tissue plasminogen activator, plasminogen activator inhibitor and CT image in chronic subdural hematoma.
- Authors
- Lim D.J.; Chung Y.G.; Park Y.K.; Song J.H.; Lee H.K.; Lee K.C.; Chu J.W.; Yang Y.S.
- Issue Date
- 1995
- Citation
- Journal of Korean medical science, v.10, no.5, pp 373 - 378
- Pages
- 6
- Indexed
- SCOPUS
- Journal Title
- Journal of Korean medical science
- Volume
- 10
- Number
- 5
- Start Page
- 373
- End Page
- 378
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/26391
- DOI
- 10.3346/jkms.1995.10.5.373
- ISSN
- 1011-8934
1598-6357
- Abstract
- The present study was performed to investigate the relationship between the concentrations of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) and the CT images in 23 cases of chronic subdural hematomas (SDHs). The concentrations of t-PA and PAI-1 were quantified by enzyme-linked immunosorbent assay (ELISA). Chronic SDHs were divided into five groups according to their appearance on computed tomography: high-density (n = 4), isodensity (n = 8), low-density (n = 5), mixed-density (n = 3), layering (n = 3) types. The volume of hematoma was measured with an image analyzing software program. The concentrations of t-PA were higher in layering (41.2 +/- 0.3 ng/ml, mean +/- standard error of the mean) and high-density (40.0 +/- 1.1 ng/ml) types compared to those of low-density (23.3 +/- 4.1 ng/ml) and iso-density (25.1 +/- 3.7 ng/ml) types. The concentrations of PAI-1 were lower in layering (95.9 +/- 1.0 ng/ml) and high-density (103.4 +/- 34.5 ng/ml) types compared to that of low-density (192.5 +/- 2.6 ng/ml) type. So the ratio between t-PA and PAI-1 (t-PA/PAI) was greater in layering and high-density types. The volume of hematoma was larger in mixed-density and layering types but statistically insignificant. These results presumably suggest that the ratio between t-PA and PAI concentration may contribute to the pathogenesis of the chronic SDH.
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- Appears in
Collections - 2. Clinical Science > Department of Neurosurgery > 1. Journal Articles
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