The associations between interleukin 10 polymorphisms and susceptibility to autoimmune uveitis a meta-analysisopen access
- Authors
- Jung, Jae Hyun; Song, Gwan Gyu; Kim, Jae-Hoon; Choi, Sung Jae
- Issue Date
- Sep-2019
- Publisher
- TERMEDIA PUBLISHING HOUSE LTD
- Keywords
- polymorphism; meta-analysis; interleukin-10; autoimmune uveitis
- Citation
- CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, v.44, no.3, pp 246 - 252
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
- Volume
- 44
- Number
- 3
- Start Page
- 246
- End Page
- 252
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2792
- DOI
- 10.5114/ceji.2019.89596
- ISSN
- 1426-3912
1644-4124
- Abstract
- Autohnmune uveitis is an ocular inflammatory disease that is associated with genetic factors. Interleukin 10 (IL-10) is an immune-regulatory cytokine of autoimmune diseases. IL-10 is considered a candidate gene for uveitis. We evaluate the association of IL-10 with susceptibility to autoimmune uveitis. The results from seven studies were pooled in the meta-analysis, covering a total of 2893 cases of uveitis and 4873 controls. Published literature from MEDLINE and Embase was retrieved. Meta-analyses were conducted on the associations between autoimmune uveitis and the -1082 A/G and -819 C/T polymorphisms of the IL-10 gene. The meta-analysis revealed no association between uveitis and the IL-10 -1082 A allele (OR = 0.91, 95% CI = 0.64-1.30, p = 0.62). The recessive, dominant, and homozygous models of the IL-10 -1082 A/G allele also suggested no association between autoimmune uveitis and each genotype. The meta-analysis revealed significant association between uveitis and the -892 C allele (OR = 0.81, 95% CI = 0.67-0.98, p = 0.03). In addition, significant association was found in homozygous models (OR = 0.58, 95% CI = 0.36-0.92, p = 0.02). However, the dominant and recessive models of the IL-10 -819 CIF polymorphisms showed no association between uveitis and each genotype. This meta-analysis showed that the -1082 A/G polymorphisms of IL-10 were not associated with autoimmune uveitis, but the -819 C/T polymorphisms were significantly associated with uveitis.
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Collections - 2. Clinical Science > Department of Rheumatology > 1. Journal Articles
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