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Efficacy of First-Line Targeted Therapy in Real-World Korean Patients with Metastatic Renal Cell Carcinoma: Focus on Sunitinib and Pazopanibopen access

Authors
Kim, Myung SooChung, Ho SeokHwang, Eu ChangJung, Seung IlKwon, Dong DeukHwang, Jun EulBae, Woo KyunPark, Jae YoungJeong, Chang WookKwak, CheolSong, CherynSeo, Seong IlByun, Seok-SooHong, Sung-HooChung, Jinsoo
Issue Date
17-Dec-2018
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Renal Cell Carcinoma; Neoplasm Metastasis; Sunitinib; Pazopanib
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.33, no.51
Indexed
SCI
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
33
Number
51
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2817
DOI
10.3346/jkms.2018.33.e325
ISSN
1011-8934
1598-6357
Abstract
Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice. Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. A multivariable Cox proportional hazard model was used to determine the prognostic factors for OS. Results: The median follow-up was 16.4 months (interquartile range, 8.3-31.3). Patients in the PZ group were older, and no significant difference was observed in the performance status (PS) between the two groups. In the SU group, the dose reduction rate was higher and the incidence of grade 3 toxicity was more frequent. The objective response rates were comparable between the two groups (SU, 32.1% vs. PZ, 36.4%). OS did not differ significantly between the two groups (SU, 36.5 months vs. PZ, 40.2 months; log-rank, P= 0.955). Body mass index, Eastern Cooperative Oncology Group PS > 2, synchronous metastasis, poor Heng risk criteria, and liver and bone metastases were associated with a shorter OS. Conclusion: Our real-world data of Korean patients with mRCC suggested that SU and PZ had similar efficacies as first-line therapy for mRCC. However, PZ was better tolerated than SU in Korean patients.
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Park, Jae Young
Ansan Hospital (Department of Urology, Ansan Hospital)
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