음향적 흐름을 이용한 혈액형 분석을 위한 새로운 방법A novel Method for Blood Typing using Acoustic Streaming
- Other Titles
- A novel Method for Blood Typing using Acoustic Streaming
- Authors
- 최현주; 장웅식; 남정훈; 임채승
- Issue Date
- Dec-2018
- Publisher
- 대한의용생체공학회
- Keywords
- Lamb wave; Blood analysis; Blood typing; Agglutination
- Citation
- 의공학회지, v.39, no.6, pp 250 - 255
- Pages
- 6
- Indexed
- KCI
- Journal Title
- 의공학회지
- Volume
- 39
- Number
- 6
- Start Page
- 250
- End Page
- 255
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/29149
- ISSN
- 1229-0807
- Abstract
- Accurate blood typing is the crucial factor for safe and successful blood transfusion and plays a very important role in organ transplantation and genetic information of forensic medicine. Microfluidic devices have been developed to overcome the limitations of the conventional blood typing methods. In this study, we demonstrate a Lamb wave-based device for simple blood typing in a sample droplet and we propose new indices for quantitative and accurate blood typing. Using Lamb wave-induced acoustic streaming in the droplet, the blood sample and the reagent can be mixed rapidly and red blood cells start to form clumps, which is agglutination. Based on the recorded image and video, the intensity of transmitted light through the sample droplet is evaluated to determine the blood type.
Effect of the concentration of suspended red blood cells was evaluated and we found that 10% concentration of suspended red blood cells was suitable to observe the difference between aggregated and non-aggregated samples.
Finally, sample with blood type A could be determined using anti-A reagent in our Lamb wave-based device. Our device enables simple and accurate blood typing, which can be applied to resource-limited environments.
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Collections - 2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
- 4. Research institute > Institute for Trauma Research > 1. Journal Articles
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