신장이식 관련 임상의와 진단검사의 대상 면역감시 현황 설문조사 결과Results of Questionnaire Survey of Current Immune Monitoring Practice of Transplant Clinicians and Clinical Pathologists in Korea: Basis for Establishment of Harmonized Immune Monitoring Guidelines
- Other Titles
- Results of Questionnaire Survey of Current Immune Monitoring Practice of Transplant Clinicians and Clinical Pathologists in Korea: Basis for Establishment of Harmonized Immune Monitoring Guidelines
- Authors
- 강은숙; 최수인; 박윤희; 박금보래; 장혜련
- Issue Date
- 2018
- Publisher
- 대한이식학회
- Keywords
- Kidney transplantation; Immunologic monitoring; Questionnaire survey; 신장이식; 면역감시; 설문조사
- Citation
- Korean Journal of Transplantation, v.32, no.2, pp 13 - 25
- Pages
- 13
- Indexed
- KCICANDI
- Journal Title
- Korean Journal of Transplantation
- Volume
- 32
- Number
- 2
- Start Page
- 13
- End Page
- 25
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/29157
- DOI
- 10.4285/jkstn.2018.32.2.13
- ISSN
- 1598-1711
2508-2604
- Abstract
- Detection of significant alloimmune response, which affects graft function and survival by effective immune monitoring, is critical for treatment decision making. However, there is no consensus regarding immune monitoring (IM) for kidney transplantation (flow KT) in Korea. The IM protocol may be affected by the level of immunological risk, the methods of desensitization and the availabilities of resources such as laboratory support and cost of tests. Questionnaire surveys designed to identify the current practices regarding immune monitoring of KT among transplant clinicians and clinical pathologists in Korea and eventually provide a basis for the establishment of harmonized immune monitoring guidelines in KT were administered as part of a Korean Society for Transplantation Sponsored Research Project. The survey results revealed significant variations in IM protocols and interpretation of tests affecting treatment decisions between institutes. Moreover, the results revealed a need to expand the histocompatibility tests into high resolution HLA typing in multiple loci and non-HLA antibody tests that facilitate the epitope analysis and eventually virtual crossmatching. The results of the questionnaire survey from clinical pathologists are addressing the urgent need for the standardization of interpretation and harmonization of results reporting in single antigen bead based HLA antibody identification. Finally, communication between clinicians and clinical pathologists to meet the clinical expectations regarding various immune monitoring tests is needed.
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Collections - 2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
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