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Cited 3 time in webofscience Cited 3 time in scopus
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Increased heat shock protein 70 expression attenuates pancreatic fibrosis induced by dibutyltin dichloride

Authors
Lee, Jae MinLee, Kwang GyunChoi, Hyuk SoonKim, Eun SunKeum, BoraSeo, Yeon SeokJeen, Yoon TaeChun, Hoon JaiLee, Hong SikUm, Soon HoKim, Chang Duck
Issue Date
Nov-2018
Publisher
TAYLOR & FRANCIS LTD
Keywords
Chronic pancreatitis; heat shock protein; pancreatic fibrosis; dibutyltin dichloride
Citation
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, v.53, no.10-11, pp.1404 - 1410
Indexed
SCIE
SCOPUS
Journal Title
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Volume
53
Number
10-11
Start Page
1404
End Page
1410
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2934
DOI
10.1080/00365521.2018.1516799
ISSN
0036-5521
Abstract
Objectives: Heat shock protein (HSP) 70 performs a chaperoning function and protects cells against injury. Although the effect of HSPs against acute inflammatory change has been proven, the relationship between HSP70 and chronic pancreatitis remains unclear. This study aimed to investigate the protective effect of increased HSP70 expression induced by thermal stress against pancreatic fibrosis in experimental chronic pancreatitis. Materials and Methods: Two experiments to evaluate pancreatic HSP70 expression induced by thermal stress and determine the effect of increased HSP70 expression against pancreatic fibrosis were performed. To investigate HSP70 expression, rats were immersed in a warm bath and sequentially killed, and pancreatic HSP70 expression was measured. To study the effect of increased HSP70 expression, pancreatic fibrosis was induced by intravenous injection of dibutyltin dichloride (DBTC) and analyzed under repeated thermal stress. The severity of pancreatic fibrosis was measured. Results: Thermal stress significantly increased HSP70 expression in the pancreas. HSP70 expression peaked at 6-12 h after warm bathing, and the increased HSP70 expression was associated with the attenuation of pancreatic fibrosis. Although pancreatic fibrosis was induced by DBTC injection, HSP70 expression induced by repeated thermal stress diminished the severity of atrophy and fibrosis. On western blot analysis, collagen type 1 expression was diminished in the increased HSP70 expression group, but not alpha-smooth muscle actin expression. Conclusions: Thermal stress could increase pancreatic HSP70 expression, and induced HSP70 expression showed a protective effect against pancreatic fibrosis. Modulation of HSP70 expression could be a potential therapeutic target in the treatment of chronic pancreatitis.
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5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Keum, Bora
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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