Persistence of solifenacin therapy in patients with overactive bladder in the clinical setting: a prospective, multicenter, observational study
- Authors
- Kim, Tae Heon; You, Hyun Wook; Park, J. H.; Lee, J. G.; Choo, M. -S.; Park, W. H.; Lee, J. Z.; Park, C. H.; Na, Y. G.; Kwon, D. D.; Lee, Kyu-Sung
- Issue Date
- Apr-2016
- Publisher
- Medicom International, Inc.
- Citation
- International Journal of Clinical Practice, v.70, no.4, pp 351 - 357
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- International Journal of Clinical Practice
- Volume
- 70
- Number
- 4
- Start Page
- 351
- End Page
- 357
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/29721
- DOI
- 10.1111/ijcp.12783
- ISSN
- 1368-5031
1742-1241
- Abstract
- Objectives
The aim of this study was to evaluate the persistence with solifenacin therapy over a 12-month period in patients with overactive bladder (OAB).
Methods
This is a 52-week long, multicenter, prospective, observational study. The subjects were individuals ≥ 18 years old with OAB symptoms for ≥ 3 months, characterised by a total OAB Symptom Score (OABSS) of ≥ 3 and OABSS urgency item score of ≥ 2. Patients were prescribed 5 mg or 10 mg of solifenacin once daily for OAB symptoms. Drug persistence, reasons for discontinuation and factors related to the persistence were evaluated.
Results
A total of 1018 patients (329 men, 689 women) with a mean age of 59 years were included. The 52-week drug persistence rate was 22.1%. The drug persistence rates at 12, 24 and 36 weeks were 72.4%, 45.8% and 31.1% respectively. The three most common reasons for discontinuing therapy included symptom improvement in 30.4%, lack of efficacy in 13.4%, and a switch to another antimuscarinic agent in 10.8%. Older patients (odds ratio = 1.02, 95% CI: 1.01–1.04), and female patients (odds ratio = 1.94, 95% CI: 1.37–2.75) were more likely to continue the medication over the 12-month period than were younger, male patients. The number of nocturia episodes was negatively correlated with drug persistence (odds ratio = 0.83, 95% CI: 0.71–0.97).
Conclusions
There was low persistence (22%) to solifenacin therapy for OAB symptoms over a 12-month period. Older patients, female patients and those with fewer episodes of nocturia were more persistent to therapy than were others.
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- Appears in
Collections - 2. Clinical Science > Department of Urology > 1. Journal Articles
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