Association between the Alu Insertion/Deletion Polymorphism in the Tissue-Type Plasminogen Activator Gene and Mirtazapine Response in Koreans with Major Depression
- Authors
- 김다슬; 장헌수; 원은수; 함병주; 이민수
- Issue Date
- 2016
- Publisher
- 대한생물정신의학회
- Keywords
- Major depressive disorder; Tissue type plasminogen activator; Alu insertion/deletion; Genetic polymorphism; Mirtazapine treatment response
- Citation
- 생물정신의학, v.23, no.4, pp 140 - 147
- Pages
- 8
- Indexed
- KCI
- Journal Title
- 생물정신의학
- Volume
- 23
- Number
- 4
- Start Page
- 140
- End Page
- 147
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/29799
- ISSN
- 1225-8709
- Abstract
- Objectives : To determine the relationship between the Alu insertion/deletion (I/D) polymorphism in the tissue-type plasminogen activator (tPA) gene and the clinical outcome of mirtazapine treatment in Korean major depressive disorder (MDD) patients.
Methods : We enrolled 422 patients in this study. Symptoms were evaluated using the 21-item Hamilton Depression Rating (HAMD- 21) Scale. After 1, 2, 4, and 8 weeks of mirtazapine treatment, the association between the Alu I/D polymorphism in the tPA gene and remission/ response outcomes were evaluated.
Results : The proportion of I/I homozygotes in responders was higher than that in non-responders, whereas the proportion of D/D homozygotes in responders was lower than that in non-responders at 8 weeks of treatment (p = 0.032, OR = 1.57). The percentage decline of HAMD-21 scores in I allele carriers was larger than that of D/D homozygotes at 2 and 8 weeks of treatment (p = 0.035 and 0.007, respectively). I allele carriers were associated with remission at 8 weeks of treatment (p = 0.047, OR = 2.2).
Conclusions : These results show that treatment response and remission to mirtazapine were associated with the Alu I/D polymorphism of the tPA gene. This suggests the Alu I/D polymorphism may be a potential genetic marker for the prediction of therapeutic response to mirtazapine treatment in patients with MDD.
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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