R347C Polymorphisms in ADRA1A Genes and Mirtazapine Treatment Response in Koreans with Major Depression
- Authors
- 구자현; 이민수; 함병주; 원은수
- Issue Date
- 2015
- Publisher
- 대한생물정신의학회
- Keywords
- Major depressive disorder; Adrenoreceptor alpha 1a; ADRA1A R347C; Mirtazapine; Treatment response
- Citation
- 생물정신의학, v.22, no.4, pp 179 - 186
- Pages
- 8
- Indexed
- KCI
- Journal Title
- 생물정신의학
- Volume
- 22
- Number
- 4
- Start Page
- 179
- End Page
- 186
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/30116
- ISSN
- 1225-8709
- Abstract
- Objectives:Adrenergic alpha 1 and 2 receptors work as pathways to control the serotonergic neuron moderation and mirtazapine acts as antagonist of these receptors. The adrenoreceptor alpha 1a (ADRA1A) gene, which encodes adrenergic alpha 1 receptor, has Arg- 347Cys genetic polymorphism and the polymorphism has strong relationship with many neuro-psychiatric diseases. In this study, we explored the relationship between ADRA1A R347C polymorphism and mirtazapine treatment response in Koreans with major depression.
Methods:352 patients enrolled in this study, and the symptoms were evaluated by 17-item Hamilton Depression Rating (HAMD-17) scale. After 1, 2, 4, 8, and 12 weeks of mirtazapine treatment, the association between ADRA1A R347C polymorphism and remission/ response outcomes was evaluated.
Results:Treatment response to mirtazapine was significantly better in T allele carriers than C allele homozygotes after 12 weeks of mirtazapine monotherapy. The percentile decline of HAMD-17 score in T allele carriers was larger than that of C allele homozygotes.
ADRA1A R347C genotypes were not significantly associated with remission.
Conclusions:The result showed that treatment response to mirtazapine was significantly associated with ADRA1A R347C genetic polymorphism. T allele carriers showed better treatment response than C allele homozygotes. It can be supposed that T allele carriers have a trend of better treatment response to mirtazapine monotherapy.
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Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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